Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases.
Identifieur interne : 000C25 ( Main/Exploration ); précédent : 000C24; suivant : 000C26Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases.
Auteurs : Mostafa Zamanian [États-Unis] ; Erik C. Andersen [États-Unis]Source :
- The FEBS journal [ 1742-4658 ] ; 2016.
Descripteurs français
- KwdFr :
- Animal génétiquement modifié, Animaux, Antihelminthiques (usage thérapeutique), Caenorhabditis elegans (génétique), Filarioidea (), Filarioidea (génétique), Filarioidea (pathogénicité), Filariose lymphatique (), Filariose lymphatique (parasitologie), Génie génétique, Génome d'helminthe, Humains, Maladies négligées (), Modèles génétiques, Nematoda (), Nematoda (génétique), Nematoda (pathogénicité), Nématodoses (), Nématodoses (parasitologie), Résistance aux substances (génétique), Systèmes CRISPR-Cas, Édition de gène (), Édition de gène (tendances).
- MESH :
- génétique : Caenorhabditis elegans, Filarioidea, Nematoda, Résistance aux substances.
- parasitologie : Filariose lymphatique, Nématodoses.
- pathogénicité : Filarioidea, Nematoda.
- tendances : Édition de gène.
- usage thérapeutique : Antihelminthiques.
- Animal génétiquement modifié, Animaux, Filarioidea, Filariose lymphatique, Génie génétique, Génome d'helminthe, Humains, Maladies négligées, Modèles génétiques, Nematoda, Nématodoses, Systèmes CRISPR-Cas, Édition de gène.
English descriptors
- KwdEn :
- Animals, Animals, Genetically Modified, Anthelmintics (therapeutic use), CRISPR-Cas Systems, Caenorhabditis elegans (genetics), Drug Resistance (genetics), Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (prevention & control), Elephantiasis, Filarial (therapy), Filarioidea (drug effects), Filarioidea (genetics), Filarioidea (pathogenicity), Gene Editing (methods), Gene Editing (trends), Genetic Engineering, Genome, Helminth, Humans, Models, Genetic, Neglected Diseases (prevention & control), Neglected Diseases (therapy), Nematoda (drug effects), Nematoda (genetics), Nematoda (pathogenicity), Nematode Infections (parasitology), Nematode Infections (prevention & control), Nematode Infections (therapy).
- MESH :
- chemical , therapeutic use : Anthelmintics.
- drug effects : Filarioidea, Nematoda.
- genetics : Caenorhabditis elegans, Drug Resistance, Filarioidea, Nematoda.
- methods : Gene Editing.
- parasitology : Elephantiasis, Filarial, Nematode Infections.
- pathogenicity : Filarioidea, Nematoda.
- prevention & control : Elephantiasis, Filarial, Neglected Diseases, Nematode Infections.
- therapy : Elephantiasis, Filarial, Neglected Diseases, Nematode Infections.
- trends : Gene Editing.
- Animals, Animals, Genetically Modified, CRISPR-Cas Systems, Genetic Engineering, Genome, Helminth, Humans, Models, Genetic.
Abstract
Neglected tropical diseases caused by parasitic nematodes inflict an immense health and socioeconomic burden throughout much of the developing world. Current estimates indicate that more than two billion people are infected with nematodes, resulting in the loss of 14 million disability-adjusted life years per annum. Although these parasites cause significant mortality, they primarily cause chronic morbidity through a wide range of severe clinical ailments. Treatment options for nematode infections are restricted to a small number of anthelmintic drugs, and the rapid expansion of anthelmintic mass drug administration raises concerns of drug resistance. Preservation of existing drugs is necessary, as well as the development of new treatment options and methods of control. We focus this review on how the democratization of CRISPR/Cas9 genome editing technology can be enlisted to improve our understanding of the biology of nematode parasites and our ability to treat the infections they cause. We will first explore how this robust method of genome manipulation can be used to newly exploit the powerful model nematode Caenorhabditis elegans for parasitology research. We will then discuss potential avenues to develop CRISPR/Cas9 editing protocols in filarial nematodes. Lastly, we will propose potential ways in which CRISPR/Cas9 can be used to engineer gene drives that target the transmission of mosquito-borne filarial nematodes.
DOI: 10.1111/febs.13781
PubMed: 27300487
Affiliations:
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Le document en format XML
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<term>Genetic Engineering</term>
<term>Genome, Helminth</term>
<term>Humans</term>
<term>Models, Genetic</term>
<term>Neglected Diseases (prevention & control)</term>
<term>Neglected Diseases (therapy)</term>
<term>Nematoda (drug effects)</term>
<term>Nematoda (genetics)</term>
<term>Nematoda (pathogenicity)</term>
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<front><div type="abstract" xml:lang="en">Neglected tropical diseases caused by parasitic nematodes inflict an immense health and socioeconomic burden throughout much of the developing world. Current estimates indicate that more than two billion people are infected with nematodes, resulting in the loss of 14 million disability-adjusted life years per annum. Although these parasites cause significant mortality, they primarily cause chronic morbidity through a wide range of severe clinical ailments. Treatment options for nematode infections are restricted to a small number of anthelmintic drugs, and the rapid expansion of anthelmintic mass drug administration raises concerns of drug resistance. Preservation of existing drugs is necessary, as well as the development of new treatment options and methods of control. We focus this review on how the democratization of CRISPR/Cas9 genome editing technology can be enlisted to improve our understanding of the biology of nematode parasites and our ability to treat the infections they cause. We will first explore how this robust method of genome manipulation can be used to newly exploit the powerful model nematode Caenorhabditis elegans for parasitology research. We will then discuss potential avenues to develop CRISPR/Cas9 editing protocols in filarial nematodes. Lastly, we will propose potential ways in which CRISPR/Cas9 can be used to engineer gene drives that target the transmission of mosquito-borne filarial nematodes.</div>
</front>
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